Evidence

Every recommendation in your Personal Wellness Report is grounded in a specific, named source — never a vague "studies show". Below is the full library of mechanisms behind those recommendations, each with the evidence grade and source shown on the report itself.

131 Harvard T.H. Chan School of Public Health
90 EFSA
52 NHS
12 British Heart Foundation
11 British Dietetic Association
5 USDA FoodData Central
1 International Journal of Dermatology

Allicin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Thiosulfinates

A natural sulphur compound produced when fresh garlic is crushed that supports heart and immune health.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory SystemDigestive System

Sources

Alpha-Linolenic Acid

Bioactive Evidence: High — Source: EFSA

Fatty Acids — Omega-3

An essential plant omega-3 fatty acid that supports heart, brain and overall health.

Glandular SystemImmune SystemRespiratory SystemCirculatory System

Sources

Anthocyanins

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonoids

Natural blue, purple and red plant pigments that help support heart, brain and blood vessel health.

Glandular SystemCirculatory SystemImmune SystemRespiratory SystemStructural SystemBrain & Nervous SystemUrinary System

Avenanthramides

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Alkaloids

Unique oat polyphenols that support cardiovascular health and healthy inflammatory balance.

Glandular SystemCirculatory System

Sources

Beta-carotene

Bioactive Evidence: High — Source: EFSA

Carotenoids — Carotenes

An orange plant pigment that the body converts into vitamin A when needed.

Brain & Nervous SystemGlandular SystemImmune SystemRespiratory SystemSkin, Hair & NailsUrinary System

Sources

Beta-glucan

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Soluble Fibre

A natural soluble fibre found mainly in oats and barley that supports heart, digestive and metabolic health.

Digestive SystemIntestinal SystemCirculatory System

Sources

Beta-sitosterol

Bioactive Evidence: High — Source: EFSA

Phytosterols — Sterols

A naturally occurring plant sterol that helps support healthy cholesterol levels.

Circulatory SystemGlandular System

Sources

Betaine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acid Derivatives

A naturally occurring compound, especially concentrated in beetroot, that supports healthy liver function and methylation.

Digestive SystemImmune SystemStructural System

Sources

Caffeine

Bioactive Evidence: High — Source: EFSA

Functional Compounds — Methylxanthines

A naturally occurring stimulant found in coffee, tea, guarana and yerba mate that supports alertness and mental performance.

Brain & Nervous SystemStructural SystemCirculatory System

Sources

Campesterol

Bioactive Evidence: High — Source: EFSA

Phytosterols — Sterols

A naturally occurring plant sterol that contributes to healthy cholesterol balance.

Circulatory SystemGlandular System

Sources

Catechins

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavanols

Natural tea and cocoa compounds that support cardiovascular health and antioxidant protection.

Glandular System

Sources

Cellulose

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Insoluble Fibre

An insoluble plant fibre that supports healthy digestion and regular bowel function.

Digestive SystemIntestinal System

Chlorogenic Acid

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Acids

A plant polyphenol that supports healthy glucose metabolism and antioxidant protection.

Glandular SystemCirculatory SystemImmune System

Choline

Bioactive Evidence: High — Source: EFSA

Functional Compounds — Methyl Donors

An essential, vitamin-like nutrient concentrated in egg yolks and organ meats that the body uses to build cell membranes and support liver and brain function.

Brain & Nervous SystemDigestive SystemImmune System

Coenzyme Q10

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Quinones

A naturally occurring compound involved in cellular energy production and antioxidant defence.

Digestive SystemIntestinal SystemGlandular SystemImmune SystemRespiratory System

Sources

Creatine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acid Derivatives

A naturally occurring compound that supports muscular performance, brain function and cellular energy production.

Brain & Nervous SystemDigestive SystemIntestinal SystemGlandular SystemStructural System

Curcumin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Curcuminoids

The principal active compound in turmeric that supports healthy inflammatory balance and antioxidant protection.

Digestive SystemIntestinal SystemGlandular SystemStructural System

Sources

Dietary Nitrate

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Nitrogen Compounds

A naturally occurring dietary nitrate that can contribute to nitric oxide production and healthy vascular function.

Circulatory SystemUrinary System

Docosahexaenoic Acid

Bioactive Evidence: High — Source: EFSA

Fatty Acids — Omega-3

A marine omega-3 fatty acid that is an important structural component of the brain and retina.

Glandular SystemCirculatory SystemBrain & Nervous SystemRespiratory SystemSkin, Hair & Nails

Sources

Eicosapentaenoic Acid

Bioactive Evidence: High — Source: EFSA

Fatty Acids — Omega-3

A marine omega-3 fatty acid that supports cardiovascular, brain and inflammatory health.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory SystemCirculatory SystemSkin, Hair & Nails

Sources

Epicatechin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavanols

A cocoa and tea flavanol associated with healthy circulation and muscle function.

Glandular SystemCirculatory System

Epigallocatechin Gallate

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavanols

The principal and most extensively studied catechin in green tea, supporting antioxidant and cardiovascular health.

Immune SystemRespiratory SystemCirculatory SystemBrain & Nervous System

Feeds Beneficial Gut Bacteria

Mechanism Evidence: High — Source: British Dietetic Association

Gut Health

Feeds the beneficial bacteria that live in the gut.

Digestive SystemIntestinal System

Ferulic Acid

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Acids

A wholegrain-bran antioxidant compound that helps protect cells from everyday oxidative stress.

Immune SystemRespiratory SystemDigestive SystemIntestinal System

Fructooligosaccharides

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Prebiotic Fibre

Short-chain prebiotic fibres that nourish beneficial gut bacteria and support digestive health.

Digestive SystemIntestinal System

Galactooligosaccharides

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Prebiotic Fibre

Prebiotic fibres that support beneficial gut bacteria, digestive health and immune function.

Digestive SystemIntestinal System

Gingerol

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenolic Ketones

The principal active compound in fresh ginger that supports digestion and healthy inflammatory balance.

Digestive SystemIntestinal SystemGlandular SystemImmune System

Glucoraphanin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Glucosinolates

A naturally occurring compound in broccoli that is converted into sulforaphane during food preparation.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory System

Guar Gum

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Viscous Soluble Fibre

A thick, gel-forming soluble fibre from the guar (cluster bean) seed that slows digestion and supports healthy cholesterol and blood sugar levels.

Circulatory SystemGlandular SystemDigestive SystemIntestinal System

Sources

Hesperidin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavanones

A citrus flavonoid that supports healthy circulation and blood vessel function.

Glandular SystemCirculatory System

Hydroxytyrosol

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Alcohols

A phenolic compound associated particularly with olives and olive-derived foods.

Immune SystemRespiratory SystemCirculatory SystemUrinary System

Improves Bowel Regularity

Mechanism Evidence: High — Source: British Dietetic Association

Gut Health

Helps support regular bowel movements.

Digestive SystemIntestinal System

Sources

Inulin

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Prebiotic Fibre

A natural prebiotic fibre that feeds beneficial gut bacteria and supports digestive wellbeing.

Digestive SystemIntestinal System

L-Arginine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acids

A conditionally essential amino acid that serves as a substrate for nitric oxide synthesis.

Circulatory SystemBrain & Nervous SystemImmune SystemRespiratory System

L-Citrulline

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acids

A non-proteinogenic amino acid that participates in arginine metabolism and nitric oxide production.

Circulatory SystemBrain & Nervous SystemImmune SystemRespiratory SystemUrinary System

L-Theanine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acids

A calming amino acid found almost exclusively in tea that supports relaxed alertness and healthy stress response.

Brain & Nervous System

Lignans

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Lignans

A group of plant polyphenols found mainly in seeds that support gut health, cardiovascular health and healthy hormone metabolism.

Glandular System

Linoleic Acid

Bioactive Evidence: High — Source: EFSA

Fatty Acids — Omega-6

An essential omega-6 fatty acid required for healthy cell membranes and normal growth.

Glandular SystemBrain & Nervous SystemCirculatory System

Sources

Lutein

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Xanthophylls

A yellow plant pigment that supports healthy vision and protects the eyes from oxidative stress.

Brain & Nervous SystemGlandular SystemCirculatory SystemSkin, Hair & Nails

Lycopene

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Carotenes

A bright red plant pigment found mainly in tomatoes that supports heart and prostate health.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory SystemSkin, Hair & Nails

Menthol

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Terpenes — Monoterpenes

A cooling mint compound that supports digestive comfort and respiratory wellbeing.

Brain & Nervous SystemGlandular SystemDigestive SystemIntestinal System

Neutralises Free Radicals

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps neutralise unstable molecules (free radicals) that can damage cells.

Immune SystemRespiratory System

Oleic Acid

Bioactive Evidence: High — Source: EFSA

Fatty Acids — Monounsaturated

The principal healthy fat found in olive oil, avocados and many nuts.

Glandular SystemCirculatory System

Pectin

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Soluble Fibre

A fruit fibre that helps support healthy digestion, beneficial gut bacteria and cholesterol balance.

Digestive SystemIntestinal SystemCirculatory System

Piperine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Alkaloids

The natural compound in black pepper that improves absorption of several nutrients.

Digestive SystemIntestinal SystemGlandular SystemStructural System

Psyllium

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Viscous Soluble Fibre

A highly viscous soluble fibre derived from psyllium husk.

Circulatory SystemDigestive SystemIntestinal SystemGlandular System

Quercetin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonols

A widely distributed plant flavonoid that supports healthy inflammation responses and cardiovascular health.

Glandular SystemDigestive SystemIntestinal SystemCirculatory SystemImmune SystemRespiratory SystemUrinary SystemBrain & Nervous System

Reduces Digestive Discomfort

Mechanism Evidence: High — Source: British Dietetic Association

Gut Health

Helps reduce everyday digestive discomfort.

Digestive SystemIntestinal System

Reduces Post-Meal Glucose Response

Mechanism Evidence: High — Source: NHS

Glucose Regulation

Helps reduce the blood sugar spike after eating.

Glandular System

Sources

Resistant Starch

Bioactive Evidence: High — Source: EFSA

Dietary Fibre — Fermentable Fibre

A special form of starch that behaves like fibre and supports digestive and metabolic health.

Digestive SystemIntestinal System

Soy Isoflavones

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phytoestrogens

Plant compounds in soy that can be metabolised by gut bacteria, including conversion of daidzein to equol in people with equol-producing microbiota.

Glandular SystemStructural System

Sulforaphane

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Isothiocyanates

A powerful plant compound from broccoli and related vegetables that activates the body's natural defence systems.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory SystemDigestive SystemCirculatory System

Supports Adrenal Function

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps support healthy adrenal gland function.

Glandular System

This mechanism represents support for normal adrenal gland function and the everyday stress response. It is not a claim to treat adrenal insufficiency, Addison's disease, or any diagnosed adrenal condition.

Supports Antiviral Defence

Mechanism Evidence: High — Source: NHS

Immune Function

Helps support the body's natural defences against viruses.

Immune System

Sources

Supports Bone Remodelling

Mechanism Evidence: High — Source: NHS

Musculoskeletal Function

Helps support the body's natural bone renewal process.

Structural System

Sources

Supports Cellular Repair

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps cells repair everyday wear and damage.

Immune SystemRespiratory System

Supports Cerebral Blood Flow

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps maintain healthy blood flow to the brain.

Brain & Nervous System

Supports Cognitive Resilience

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support healthy brain function over time.

Brain & Nervous System

Supports Collagen Formation

Mechanism Evidence: High — Source: NHS

Musculoskeletal Function

Helps the body produce collagen, a key structural protein.

Structural SystemSkin, Hair & Nails

Supports Connective Tissue Integrity

Mechanism Evidence: High — Source: NHS

Musculoskeletal Function

Helps keep connective tissue, like tendons and ligaments, strong.

Structural SystemSkin, Hair & Nails

Supports Fluid & Electrolyte Balance

Mechanism Evidence: High — Source: EFSA

Electrolyte Balance

Electrolytes help keep the right balance of water inside and around your cells.

Circulatory SystemStructural System

Sources

Supports Glutathione Synthesis

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Detoxification

Helps the body produce and recycle glutathione, its main natural detox molecule.

Digestive SystemImmune System

Sources

Supports Glycaemic Stability

Mechanism Evidence: High — Source: NHS

Glucose Regulation

Helps keep blood sugar levels steady.

Glandular System

Supports Glycogen Storage

Mechanism Evidence: High — Source: NHS

Glucose Regulation

Helps the body store energy as glycogen for later use.

Glandular System

Sources

Supports Healthy Ageing of Musculoskeletal System

Mechanism Evidence: High — Source: NHS

Musculoskeletal Function

Helps support strong bones, muscles and joints as part of healthy ageing.

Structural System

Supports Healthy Blood Flow

Mechanism Evidence: High — Source: British Heart Foundation

Vascular Function

Helps blood flow more easily around the body.

Circulatory System

Supports Healthy Gut pH

Mechanism Evidence: High — Source: British Dietetic Association

Gut Health

Helps maintain a healthy acid balance in the gut.

Digestive SystemIntestinal System

Supports Healthy Inflammatory Balance

Mechanism Evidence: High — Source: NHS

Immune Function

Helps keep the body's inflammatory response balanced.

Immune System

Sources

Supports Healthy Lipoprotein Balance

Mechanism Evidence: High — Source: EFSA

Lipid Metabolism

Helps keep the different types of cholesterol-carrying particles in a healthy balance.

Circulatory System

Supports Healthy Triglyceride Metabolism

Mechanism Evidence: High — Source: EFSA

Lipid Metabolism

Helps keep blood fat (triglyceride) levels in a healthy range.

Circulatory System

Sources

Supports Hepatic Cellular Protection

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Detoxification

Helps protect liver cells while the liver performs detoxification.

Digestive SystemImmune System

Supports Homocysteine Methylation Metabolism

Mechanism Evidence: High — Source: EFSA

Methylation Metabolism

B vitamins help your body process and recycle an amino acid called homocysteine through its normal metabolic pathway.

Circulatory SystemBrain & Nervous System

Describes normal one-carbon/methylation metabolism; not a claim of reduced cardiovascular or cognitive disease risk.

Sources

Supports Hormonal Homeostasis

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps keep the body's hormones in overall balance.

Glandular System

This mechanism represents support for the body's normal overall hormonal balance. It is not a claim to treat a hormonal disorder or replace hormone therapy.

Supports Immune Cell Signalling

Mechanism Evidence: High — Source: NHS

Immune Function

Helps immune cells communicate with each other effectively.

Immune System

Supports Immune Resilience

Mechanism Evidence: High — Source: NHS

Immune Function

Helps support a resilient, well-functioning immune system.

Immune System

Supports Iron-Dependent Oxygen Transport

Mechanism Evidence: High — Source: EFSA

Micronutrient Transport & Cofactor Function

Iron helps your blood pick up and carry oxygen around your body.

Circulatory System

Describes normal iron transport physiology; not intended to imply diagnosis, prevention or treatment of anaemia or iron-deficiency conditions.

Supports LDL Reduction

Mechanism Evidence: High — Source: EFSA

Lipid Metabolism

Helps lower LDL, often called 'bad' cholesterol.

Circulatory System

Supports Mitochondrial Resilience

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps protect the energy-producing parts of cells.

Immune SystemRespiratory System

Supports Nervous System Function

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support healthy nervous system function overall.

Brain & Nervous System

Sources

Supports Phase II Conjugation

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Detoxification

Helps the liver make toxins water-soluble so they can be removed safely.

Digestive SystemImmune System

Supports Skin Cell Renewal

Mechanism Evidence: High — Source: EFSA

Dermatological Function

Helps skin renew itself at a healthy pace and maintain its normal structure.

Skin, Hair & Nails

This reflects normal skin-cell-turnover physiology (EFSA-authorised claims for vitamin A and zinc's maintenance of normal skin) and does not address diagnosed skin conditions such as acne, eczema or psoriasis, and is not an anti-ageing or cosmetic-transformation claim.

Sources

Supports Thyroid Function

Mechanism Evidence: High — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps support healthy thyroid function.

Glandular System

This mechanism represents support for normal thyroid function. It is not a claim to treat thyroid disorders such as hypothyroidism or hyperthyroidism, or to replace thyroid medication.

Sources

Supports Vascular Elasticity

Mechanism Evidence: High — Source: British Heart Foundation

Vascular Function

Helps keep blood vessels flexible and responsive.

Circulatory System

Sources

Supports Vascular Repair

Mechanism Evidence: High — Source: British Heart Foundation

Vascular Function

Helps the body repair and maintain blood vessel walls.

Circulatory System

Sources

Supports Zinc-Dependent Enzyme Cofactor Activity

Mechanism Evidence: High — Source: EFSA

Micronutrient Transport & Cofactor Function

Zinc acts as a helper molecule that switches on hundreds of enzymes your body relies on for everyday metabolism.

Glandular System

Sources

Taurine

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acid Derivatives

A sulphur-containing amino acid derivative that supports cardiovascular, muscular and neurological function.

Glandular SystemBrain & Nervous SystemCirculatory System

Zeaxanthin

Bioactive Evidence: High — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Xanthophylls

A carotenoid that works alongside lutein to support healthy eyesight and retinal protection.

Glandular SystemBrain & Nervous SystemSkin, Hair & Nails

4-Hydroxyisoleucine

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acid Derivatives

A unique amino acid found almost exclusively in fenugreek seed, studied for supporting healthy insulin response.

Glandular System

6-Paradol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenolic Ketones

A pungent compound in grains of paradise, related to ginger's gingerol, studied for supporting energy expenditure.

Glandular SystemCirculatory System

8-Prenylnaringenin

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Phytoestrogens

A plant compound found almost exclusively in hops, recognised as one of the most potent plant oestrogen-like compounds identified, studied mainly in relation to menopausal wellbeing.

Glandular System

Acetic Acid

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Organic Acids

The main active compound in vinegar, shown in studies to modestly reduce blood sugar spikes after carbohydrate-containing meals.

Glandular System

Activates Endogenous Antioxidant Pathways

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps switch on the body's own natural antioxidant defences.

Immune SystemRespiratory System

Alginate

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Viscous Soluble Fibre

The main structural fibre in brown seaweed cell walls, which forms a thick gel in water and is widely used as a natural food thickener.

Circulatory SystemGlandular System

Allyl Isothiocyanate

Bioactive Evidence: Moderate — Source: EFSA

Sulphur Compounds — Isothiocyanates

The pungent compound behind the sharp heat of mustard, wasabi and horseradish, with documented antimicrobial activity.

Digestive SystemImmune System

Alpha-carotene

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Carotenes

A naturally occurring carotenoid that supports antioxidant protection and vitamin A production.

Glandular SystemBrain & Nervous SystemImmune SystemRespiratory SystemUrinary SystemSkin, Hair & Nails

Anethole

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Phenylpropanoids

The naturally sweet, aniseed-flavoured compound found in star anise and related spices, traditionally used to support digestive comfort.

Digestive SystemIntestinal System

Sources

Arabinoxylan

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Cereal Fibre

A wholegrain fibre that supports beneficial gut bacteria and healthy glucose metabolism.

Digestive SystemIntestinal System

Astaxanthin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Ketocarotenoids

A deep red marine carotenoid recognised for its exceptionally strong antioxidant activity.

Brain & Nervous SystemGlandular SystemSkin, Hair & NailsCirculatory System

Beta-Caryophyllene

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Sesquiterpenes

A peppery-woody aromatic compound found in black pepper and cloves that supports the body's normal inflammatory balance.

Immune SystemRespiratory System

Sources

Betalains

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Plant Pigments

A family of water-soluble pigments characteristic of beetroot and certain other plants.

Immune SystemRespiratory SystemDigestive System

Sources

Bile Acid Binding

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Helps remove cholesterol from the body by binding to bile acids in the gut.

Circulatory System

Bromelain

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Proteolytic Enzymes

A mixture of protein-digesting enzymes found in pineapple stems and fruit, best known for helping break down protein and easing digestive discomfort.

Digestive SystemIntestinal System

Butyrate (Butyric Acid)

Bioactive Evidence: Moderate — Source: USDA FoodData Central

Fatty Acids — Short-Chain Fatty Acids

A short-chain fat naturally concentrated in dairy fat, especially butter, that is also the main fuel colon cells use when gut bacteria ferment fibre.

Digestive SystemIntestinal System

Caffeoylquinic Acids

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Acids

A family of phenolic acids found prominently in artichoke, including chlorogenic acid and dicaffeoylquinic acids such as cynarin.

Digestive SystemImmune System

Capsaicin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Capsaicinoids

The natural compound responsible for the heat of chilli peppers that supports healthy metabolism.

Digestive SystemIntestinal SystemGlandular System

Capsanthin

Bioactive Evidence: Moderate — Source: EFSA

Carotenoids — Ketocarotenoids

The natural red pigment in ripe chilli peppers and paprika that contributes antioxidant activity.

Immune SystemRespiratory SystemSkin, Hair & Nails

Carnosic Acid

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Diterpenes

A natural antioxidant compound found in rosemary that helps activate the body's own protective antioxidant defences.

Immune SystemRespiratory System

Carnosine

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Amino Acid Derivatives

A natural compound found in animal muscle that helps buffer acid build-up during intense exercise and acts as an antioxidant within muscle tissue.

Structural SystemImmune SystemRespiratory System

Carvacrol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Terpenes — Monoterpenes

A naturally occurring oregano compound that supports healthy microbial balance and antioxidant defence.

Glandular System

Sources

Carvone

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Monoterpenes

The main aromatic compound in caraway and dill seed, traditionally associated with easing digestive discomfort.

Digestive SystemIntestinal System

Casein Phosphopeptides

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Bioactive Peptides

Small protein fragments released from milk casein during digestion that help keep minerals like calcium available for absorption in the gut.

Digestive SystemIntestinal SystemStructural System

Chitin-Glucan Complex

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Fungal Fibre

A natural fibre found in the cell walls of mushrooms and mycoprotein foods like Quorn, related to but distinct from the fibre found in oats.

Circulatory SystemGlandular System

Chlorophyllin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Plant Pigments

A water-soluble chlorophyll derivative used in foods and nutritional formulations.

Immune SystemRespiratory SystemDigestive System

Chondroitin Sulfate

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Joint Support Compounds

A structural component of cartilage, often paired with glucosamine to support joint health.

Structural SystemSkin, Hair & NailsUrinary System

Cinnamaldehyde

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenylpropanoids

The principal active compound in cinnamon that supports healthy blood glucose metabolism and antioxidant protection.

Glandular SystemDigestive SystemIntestinal System

Citral

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Monoterpenes

The lemon-scented compound that gives lemongrass its characteristic aroma, with documented antimicrobial activity.

Immune SystemRespiratory System

Citric Acid

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Organic Acids

A natural acid abundant in citrus fruits that, once absorbed, is excreted in urine as citrate - helping keep urinary minerals dissolved.

Urinary System

Sources

Conjugated Linoleic Acid (CLA)

Bioactive Evidence: Moderate — Source: USDA FoodData Central

Fatty Acids — Conjugated Fatty Acids

A naturally occurring fat found in milk and cheese from cows, sheep, goats and buffalo, formed by bacteria in the animal's gut.

Circulatory System

Cordycepin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Nucleoside Analogues

The signature compound found in Cordyceps fungus, studied for supporting cellular energy production and exercise capacity.

Brain & Nervous SystemGlandular SystemStructural SystemImmune SystemRespiratory System

Cranberry A-Type Proanthocyanidins

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavan-3-ol Oligomers

A structurally distinctive form of proanthocyanidin found almost uniquely in cranberries, linked to urinary tract health.

Urinary System

Crocin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Carotenoid Glycosides

The compound that gives saffron its vivid golden-red colour, studied for supporting healthy mood and antioxidant defences.

Brain & Nervous System

Cuminaldehyde

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Aromatic Aldehydes

The principal aroma compound in cumin seed, with antioxidant and antimicrobial properties in laboratory studies.

Digestive SystemIntestinal SystemImmune SystemRespiratory System

D-Mannose

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Urinary Tract Compounds

A naturally occurring simple sugar, found in small amounts in cranberries and several other fruits, studied for helping stop certain bacteria from sticking to the urinary tract lining.

Urinary System

D-Ribose

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Pentose Sugars

A five-carbon sugar that forms part of the molecular structure of nucleotides and nucleic acids.

Brain & Nervous SystemGlandular SystemStructural SystemImmune SystemRespiratory System

Sources

Daidzein

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phytoestrogens

The second major soy isoflavone, notable because gut bacteria in some people convert it into the more potent compound equol.

Glandular System

Diallyl Sulphide

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Sulphides

A garlic-derived sulphur compound that supports healthy detoxification and antioxidant protection.

Brain & Nervous SystemGlandular SystemImmune SystemRespiratory SystemDigestive System

Sources

Ellagic Acid

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phenolic Acids

A berry-derived antioxidant that supports cellular protection and healthy inflammatory balance.

Glandular SystemImmune SystemRespiratory SystemStructural SystemSkin, Hair & Nails

Ellagitannins

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Ellagitannins

The parent polyphenols in pomegranate, walnuts and berries that break down into ellagic acid, and further, into gut-bacteria-made urolithins.

Immune SystemRespiratory SystemDigestive SystemIntestinal SystemCirculatory System

Ergothioneine

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Amino Acid Derivatives

A unique antioxidant amino acid that mushrooms are especially rich in, sometimes called the 'longevity vitamin' because the body actively collects and stores it in stressed tissues.

Immune SystemRespiratory System

Sources

Eucalyptol

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Monoterpenes

A fresh, camphor-like aromatic compound found in bay leaves and other culinary spices, traditionally associated with easy breathing.

Respiratory System

Eugenol

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Phenylpropanoids

A warm, clove-like aromatic compound found in tulsi, cloves and several culinary herbs, valued for its antimicrobial and antioxidant properties.

Immune SystemRespiratory System

Fisetin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonols

A flavonoid found particularly in strawberries that supports antioxidant protection and healthy cellular ageing.

Immune SystemRespiratory SystemBrain & Nervous System

Fucoidan

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Sulfated Polysaccharides

A sticky, gel-forming fibre unique to brown seaweeds that is being studied for how it interacts with the immune system.

Immune SystemCirculatory System

Sources

Fucoxanthin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Carotenoids — Xanthophylls

A brown-pigment carotenoid unique to brown seaweeds and algae, studied for antioxidant and metabolic effects.

Immune SystemRespiratory SystemGlandular System

Sources

GABA (Gamma-Aminobutyric Acid)

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acid Derivatives

GABA is a calming compound naturally produced by bacteria and fungi during fermentation that may support a relaxed nervous system.

Brain & Nervous System

Gamma-Linolenic Acid (GLA)

Bioactive Evidence: Moderate — Source: EFSA

Fatty Acids — Omega-6

A type of omega-6 fat found in a small number of seed oils that the body converts into signalling molecules involved in normal inflammatory balance.

Immune SystemSkin, Hair & Nails

Sources

Gamma-Oryzanol

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Steryl Ferulates

A natural compound found almost exclusively in rice bran oil that combines plant-sterol and antioxidant properties.

Circulatory SystemImmune SystemRespiratory System

Genistein

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Phytoestrogens

The most abundant individual isoflavone in soy, studied separately from the general soy isoflavone group for its distinct hormonal and bone-related actions.

Glandular SystemStructural System

Ginsenosides

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Adaptogenic Compounds

The characteristic active compounds of Korean/Panax ginseng root, traditionally used to support energy and mental alertness.

Structural SystemBrain & Nervous SystemGlandular System

Glucomannan

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Viscous Soluble Fibre

The near-total soluble fibre that makes up konjac, forming a thick gel in the digestive tract.

Glandular System

Glucosamine Hydrochloride

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Joint Support Compounds

A natural component of joint cartilage, commonly taken to support joint comfort and mobility.

Structural SystemSkin, Hair & NailsUrinary System

Hemicellulose

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Mixed Fibre

A naturally occurring plant fibre that supports digestive health and a healthy gut microbiome.

Digestive SystemIntestinal System

Hyaluronic Acid

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Structural Polysaccharides

A naturally occurring polysaccharide found in skin and joint fluid that holds water and supports hydration and joint cushioning.

Structural SystemSkin, Hair & NailsUrinary System

Hydrolyzed Collagen Peptides

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Structural Proteins

Collagen protein broken down into small, easily absorbed peptides that support skin, hair, nail, joint and connective tissue health.

Structural SystemSkin, Hair & Nails

Improves Insulin Sensitivity

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps the body respond to insulin more effectively.

Glandular System

Improves Satiety

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps you feel fuller for longer after eating.

Glandular System

Sources

Increases Short-Chain Fatty Acid Production

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps gut bacteria produce beneficial short-chain fatty acids.

Digestive SystemIntestinal System

Indole-3-Carbinol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Glucosinolates

A compound formed from cruciferous vegetables that supports the body's natural detoxification processes.

Glandular SystemDigestive SystemImmune System

Sources

Kaempferol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonols

A flavonoid found in leafy greens and vegetables that supports healthy cellular protection.

Glandular System

L-Carnitine

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Amino Acid Derivatives

A compound, especially concentrated in red meat and heart, that shuttles fat into cells' energy-producing mitochondria.

Brain & Nervous SystemGlandular SystemStructural SystemCirculatory System

Sources

L-Cystine

Bioactive Evidence: Moderate — Source: EFSA

Sulphur Compounds — Sulfur Amino Acids

A sulfur-containing amino acid that is a major structural building block of hair and nail keratin.

Skin, Hair & Nails

L-Glutamine

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Amino Acids

A conditionally essential amino acid involved in nitrogen transport and cellular metabolism.

Digestive SystemIntestinal SystemImmune SystemBrain & Nervous SystemGlandular SystemStructural System

Lauric Acid

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Fatty Acids — Medium-Chain Saturated

A saturated fat found mainly in coconut that the body processes differently from most other fats, using it quickly for energy rather than storing it, and which is also studied for natural antimicrobial properties.

Circulatory SystemImmune System

Sources

Lignin

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Insoluble Fibre

A structural plant compound that contributes to healthy bowel function and digestive wellbeing.

Digestive SystemIntestinal System

Limonene

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Terpenes — Monoterpenes

A citrus terpene that supports healthy digestion and antioxidant defence.

Glandular SystemBrain & Nervous SystemDigestive SystemIntestinal System

Linalool

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Monoterpenes

A floral, citrus-like monoterpene found in coriander seed and many aromatic herbs, associated with a calming effect.

Brain & Nervous System

Live Bacterial Cultures (Probiotics)

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Live Cultures

Beneficial live bacteria found in fermented dairy foods like kefir, live yogurt-style drinks and cultured buttermilk that can support a healthy gut.

Digestive SystemIntestinal SystemImmune SystemUrinary System

Lysozyme

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Antimicrobial Proteins

A natural enzyme in raw egg white that can break down the outer walls of certain bacteria.

Immune System

Sources

Medium-Chain Triglycerides (MCTs)

Bioactive Evidence: Moderate — Source: USDA FoodData Central

Fatty Acids — Medium-Chain

A group of fats with shorter carbon chains than most dietary fats, absorbed and used for quick energy more readily than typical long-chain fats.

Circulatory SystemBrain & Nervous SystemGlandular SystemStructural System

Melatonin

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Indoleamines

A naturally occurring compound found in small amounts in certain foods that supports healthy sleep regulation.

Brain & Nervous SystemImmune SystemRespiratory System

Methylsulfonylmethane (MSM)

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Joint Support Compounds

A naturally occurring sulfur compound often used alongside glucosamine and chondroitin for joint comfort.

Structural SystemImmune System

Naringenin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavanones

A citrus polyphenol that supports metabolic health and antioxidant defence.

Glandular SystemCirculatory System

Naringin

Bioactive Evidence: Moderate — Source: NHS

Polyphenols — Flavanones

The bitter-tasting glycoside in grapefruit that your gut converts into naringenin, and the compound behind grapefruit's well-known drug interactions.

Immune SystemRespiratory SystemCirculatory System

Nattokinase

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Proteolytic Enzymes

Nattokinase is an enzyme unique to natto that helps break down fibrin, a protein involved in blood clot structure, supporting normal blood flow.

Circulatory System

Oleuropein

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Secoiridoids

A characteristic olive polyphenol found especially in olive leaves and unripe olives.

Immune SystemRespiratory SystemCirculatory System

Palmitoleic Acid (Omega-7)

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Fatty Acids — Omega-7

A less common fat found in a handful of foods like sea buckthorn that researchers have studied for its role in normal fat and blood sugar handling.

Circulatory SystemGlandular SystemSkin, Hair & Nails

Papain

Bioactive Evidence: Moderate — Source: USDA FoodData Central

Functional Compounds — Proteolytic Enzymes

A protein-digesting enzyme papaya is famous for, most concentrated in the fruit's latex and unripe flesh.

Digestive SystemIntestinal System

Sources

Phaseolamin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Enzyme Inhibitors

A natural protein from white kidney beans that blocks the enzyme the body uses to digest starch.

Glandular System

Phycocyanin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phycobiliproteins

A blue phycobiliprotein pigment characteristic of spirulina and other cyanobacteria.

Immune SystemRespiratory SystemDigestive System

Sources

Piceatannol

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Stilbenes

A resveratrol-related plant compound concentrated in passion fruit seeds, being studied for how it supports blood vessel and metabolic health.

Immune SystemRespiratory SystemCirculatory System

Pinolenic Acid

Bioactive Evidence: Moderate — Source: EFSA

Fatty Acids — Non-Methylene-Interrupted Fatty Acids

A distinctive fat found almost exclusively in pine nuts that may help you feel fuller for longer after eating.

Glandular SystemCirculatory System

Plant Ceramides

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Sphingolipids

Plant-based fats that resemble the natural lipids holding skin's outer barrier together.

Skin, Hair & Nails

Proanthocyanidins

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavan-3-ol Oligomers

A family of flavonoid polymers found particularly in grape skins, seeds and other plant foods.

Immune SystemRespiratory SystemCirculatory SystemDigestive SystemStructural SystemSkin, Hair & Nails

Protects Cellular Membranes

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps protect the outer membrane of cells from damage.

Immune SystemRespiratory System

Sources

Protects Proteins from Oxidation

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps protect proteins in the body from oxidative damage.

Immune SystemRespiratory System

Punicalagins

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Ellagitannins

The large antioxidant compounds that make pomegranate juice so potent, and the raw material your gut bacteria turn into urolithins.

Immune SystemRespiratory SystemCirculatory SystemDigestive SystemIntestinal System

Sources

Punicic Acid

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Fatty Acids — Conjugated Fatty Acids

An unusual polyunsaturated fat found in pomegranate seeds, structurally similar to CLA.

Circulatory SystemImmune System

Reduces Cholesterol Absorption

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Reduces how much cholesterol from food gets absorbed into the body.

Circulatory System

Reduces DNA Oxidative Damage

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps protect DNA from oxidative damage.

Immune SystemRespiratory System

Reduces Glycaemic Variability

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps reduce large swings in blood sugar levels.

Glandular System

Sources

Reduces Oxidative Stress

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps reduce harmful oxidative damage in the body.

Immune SystemRespiratory System

Sources

Resistant Dextrin

Bioactive Evidence: Moderate — Source: EFSA

Dietary Fibre — Resistant Fibre

A soluble, slowly digested fibre that reaches the large intestine for microbial fermentation.

Digestive SystemIntestinal System

Resveratrol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Stilbenes

A natural plant compound best known from grapes that supports healthy ageing and cardiovascular health.

Glandular SystemDigestive SystemIntestinal SystemImmune SystemRespiratory SystemBrain & Nervous SystemCirculatory System

Rosavins

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenylpropanoids

A group of characteristic phenylpropanoid glycosides found in Rhodiola rosea root.

Immune SystemRespiratory SystemGlandular System

Rosmarinic Acid

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Phenolic Acids

A polyphenol common in mint-family and borage-family herbs that supports the body's natural antioxidant and inflammatory-balance processes.

Immune SystemRespiratory SystemBrain & Nervous System

Rutin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonols

A flavonoid glycoside, related to quercetin, found particularly in buckwheat and citrus that supports blood vessel and antioxidant health.

Circulatory SystemImmune SystemRespiratory System

Sources

S-Allyl Cysteine

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Cysteine Derivatives

A stable, odourless sulphur compound that builds up in garlic as it slowly ages into black garlic, linked to notably higher antioxidant activity than fresh garlic.

Immune SystemRespiratory System

S-Methyl Cysteine Sulfoxide

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Sulphur Compounds — Sulfoxides

A naturally occurring sulphur compound found in onions and brassica vegetables that supports healthy metabolism.

Brain & Nervous SystemGlandular System

Sources

Salidroside

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenylpropanoid Glycosides

A phenylpropanoid glycoside found in Rhodiola species.

Immune SystemRespiratory SystemDigestive SystemGlandular System

Saponins

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Saponins

Natural soap-like plant compounds found in legumes such as chickpeas, soybeans and peas that give aquafaba its egg-white-like foaming ability, and which are being studied for effects on cholesterol and gut bacteria.

Circulatory System

Schisandrin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Lignans

A characteristic lignan found in Schisandra berries.

Immune SystemRespiratory SystemDigestive SystemGlandular System

Sources

Shogaol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Phenolic Ketones

A bioactive compound formed when ginger is dried or heated that supports antioxidant and inflammatory balance.

Glandular SystemDigestive SystemIntestinal System

Silymarin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Flavonolignans

The signature compound complex found in milk thistle seeds, long used traditionally and increasingly studied for supporting liver cell health.

Digestive SystemImmune System

Slows Glucose Absorption

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Slows down how quickly sugar from food enters the bloodstream.

Glandular System

Squalene

Bioactive Evidence: Moderate — Source: EFSA

Terpenes — Triterpenes

A natural oil compound, especially abundant in olive and camellia (tea seed) oil, with antioxidant properties and a role in the skin's own natural oils.

Immune SystemRespiratory SystemSkin, Hair & Nails

Stigmasterol

Bioactive Evidence: Moderate — Source: EFSA

Phytosterols — Sterols

A naturally occurring plant sterol found in legumes, seeds and vegetable oils that supports healthy cholesterol metabolism.

Circulatory SystemGlandular System

Supports Adaptive Immune Function

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps support the body's targeted, longer-term immune defences.

Immune System

Supports Airway Barrier Integrity

Mechanism Evidence: Moderate — Source: NHS

Respiratory Function

Helps protect the lining of the airways.

Respiratory System

Supports Antimicrobial Defence

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps support the body's natural defences against harmful microbes.

Immune System

Sources

Supports Blood-Brain Barrier Integrity

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps protect the barrier that shields the brain from harmful substances in the blood.

Brain & Nervous System

Supports Bone Mineralisation

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps the body build strong, well-mineralised bones.

Structural System

Supports Capillary Integrity

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps keep the smallest blood vessels strong and less prone to leaking.

Circulatory System

Supports Cellular Energy Metabolism

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Energy Metabolism

Helps cells produce and use energy efficiently.

Brain & Nervous SystemGlandular SystemStructural System

Supports Circadian Melatonin Precursor Pathway

Mechanism Evidence: Moderate — Source: NHS

Brain Function

Certain nutrients feed the body's natural pathway for making melatonin, the hormone that helps signal night-time.

Brain & Nervous System

Describes normal circadian biochemistry; not intended as a claim to treat insomnia or any sleep disorder.

Supports Dermal Hydration & Water-Retention

Mechanism Evidence: Moderate — Source: EFSA

Dermatological Function

Hyaluronic acid helps the deeper layer of skin hold onto water, supporting skin's moisture and plumpness.

Skin, Hair & Nails

Refers to measurable skin hydration/moisture content only, not to wrinkle reduction, anti-ageing outcomes, or treatment of any skin condition.

Supports Digestive Enzyme Activity

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps the body's digestive enzymes work effectively.

Digestive SystemIntestinal System

Sources

Supports Endocrine Resilience

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps the body's hormone-producing glands stay resilient under stress.

Glandular System

This mechanism represents support for the endocrine system's normal capacity to adapt to everyday physiological stress. It is not a claim to treat an endocrine disorder or replace medical management of adrenal or thyroid disease.

Supports Endothelial Function

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps keep the inner lining of blood vessels healthy.

Circulatory System

Sources

Supports Epidermal Lipid Barrier & Reduces Water Loss

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Dermatological Function

Essential fatty acids and plant-derived ceramides help maintain the skin's natural barrier, which keeps moisture in.

Skin, Hair & Nails

Describes normal barrier-lipid physiology; this is not a treatment mechanism for eczema, dermatitis, psoriasis, or any diagnosed skin condition.

Supports Glucose Uptake

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps cells take up glucose from the blood for energy.

Glandular System

Sources

Supports Gut Barrier Integrity

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps keep the lining of the gut strong and well-sealed.

Digestive SystemIntestinal System

Sources

Supports Hair & Nail Keratin Production

Mechanism Evidence: Moderate — Source: NHS

Dermatological Function

Helps the body get the nutrients it needs to build strong hair and nails.

Skin, Hair & Nails

This reflects nutrient support for keratin production and does not address hair loss caused by hormonal, genetic or medical conditions such as androgenetic alopecia. If you're experiencing significant or sudden hair thinning, consult a healthcare professional.

Sources

Supports Hair Pigmentation

Mechanism Evidence: Moderate — Source: International Journal of Dermatology

Dermatological Function

Copper is needed to produce the pigment that gives hair its natural colour.

Skin, Hair & Nails

This describes copper's established biochemical role in melanin synthesis (low serum copper has been associated with premature hair greying in observational studies). It is not evidence that dietary copper prevents, slows or reverses grey hair in people who are not copper deficient -- hair greying is primarily driven by age-related and genetic factors.

Sources

Supports HDL Maintenance

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Helps maintain healthy levels of HDL, often called 'good' cholesterol.

Circulatory System

Supports Healthy Ageing

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps support the body's natural, healthy ageing processes.

Immune SystemRespiratory System

Sources

Supports Healthy Airway Inflammatory Balance

Mechanism Evidence: Moderate — Source: NHS

Respiratory Function

Helps keep inflammation in the airways balanced.

Respiratory System

Supports Healthy Airway Reactivity

Mechanism Evidence: Moderate — Source: NHS

Respiratory Function

Helps keep the airways responding normally rather than overreacting.

Respiratory System

Supports Healthy Blood Pressure Regulation

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps support healthy blood pressure.

Circulatory System

Supports Healthy Cholesterol Metabolism

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Helps keep cholesterol levels in a healthy range.

Circulatory System

Sources

Supports Healthy Cytokine Balance

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps keep the immune system's signalling molecules in balance.

Immune System

Sources

Supports Healthy Energy Regulation

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps keep energy levels steady throughout the day.

Glandular System

Sources

Supports Healthy Fibrinolytic Balance

Mechanism Evidence: Moderate — Source: EFSA

Vascular Function

This describes how the body naturally keeps blood-clot proteins broken down and cleared as part of everyday circulation maintenance.

Circulatory System

This reflects support for the body's normal clot-clearing process and should not be read as prevention or treatment of blood clots, deep vein thrombosis, stroke or cardiovascular disease; anyone on anticoagulant or antiplatelet medication should seek medical advice before using concentrated nattokinase supplements.

Supports Healthy Mood

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support healthy mood.

Brain & Nervous System

Supports Healthy Platelet Function

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps keep blood platelets functioning normally.

Circulatory System

Supports Healthy Urinary Citrate Levels

Mechanism Evidence: Moderate — Source: NHS

Renal Function

Helps keep minerals in urine dissolved rather than clumping together.

Urinary System

This mechanism reflects general support for healthy urinary mineral balance through diet. It is not a treatment for kidney stones and does not replace medical management of a diagnosed stone-forming condition.

Sources

Supports Hormone Synthesis

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps the body produce the hormones it needs.

Glandular System

This mechanism represents support for normal physiological hormone production. It is not a claim to treat a hormonal disorder or replace hormone therapy.

Supports Immune Surveillance

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps the immune system keep watch for potential threats.

Immune System

Supports Innate Immune Function

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps support the body's first line of immune defence.

Immune System

Supports Insulin Signalling

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps the body's cells respond properly to insulin.

Glandular System

Sources

Supports Joint Health

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps support healthy, comfortable joints.

Structural System

Supports Lipid Oxidation

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Helps the body burn fat for energy.

Circulatory System

Supports Lipid Transport

Mechanism Evidence: Moderate — Source: EFSA

Lipid Metabolism

Helps the body move fats and cholesterol around efficiently.

Circulatory System

Supports Memory Formation

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support the brain's ability to form new memories.

Brain & Nervous System

Supports Menopausal Transition Resilience

Mechanism Evidence: Moderate — Source: NHS

Glandular

Supports physiological adaptation during the menopausal transition.

Glandular System

This mechanism represents physiological adaptation during the menopausal transition. It is not a claim to treat menopause, replace hormone therapy, or normalise hormone concentrations.

Supports Mental Performance

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support focus and mental performance.

Brain & Nervous System

Supports Microbial Bile Acid Metabolism

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Gut Health

Gut bacteria convert bile acids into new forms that act as chemical messengers in the digestive system.

Digestive SystemIntestinal System

Reflects an active, evolving area of microbiome research; not a claim of clinical effect on any bile-acid-related condition.

Supports Microbiome Diversity

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps support a diverse and healthy population of gut bacteria.

Digestive SystemIntestinal System

Supports Microcirculation

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps improve blood flow through the smallest blood vessels.

Circulatory System

Sources

Supports Mucosal Health

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps keep the protective lining of the gut healthy.

Digestive SystemIntestinal System

Sources

Supports Muscle Protein Synthesis

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps the body build and repair muscle tissue.

Structural System

Sources

Supports Muscle Recovery

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps muscles recover after physical activity.

Structural System

Sources

Supports Neuronal Antioxidant Defence

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps protect brain cells from oxidative damage.

Brain & Nervous System

Supports Neuroprotection

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps protect brain cells from everyday stress and damage.

Brain & Nervous System

Supports Neurotransmitter Synthesis

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps the brain produce the chemical messengers it needs to function.

Brain & Nervous System

Sources

Supports Neurotrophic Signalling

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps support the growth signals that keep brain cells healthy and adaptable.

Brain & Nervous System

Supports Nitric Oxide Production

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps the body produce nitric oxide, which relaxes blood vessels.

Circulatory System

Sources

Supports Nutrient Absorption

Mechanism Evidence: Moderate — Source: British Dietetic Association

Gut Health

Helps the body absorb nutrients from food effectively.

Digestive SystemIntestinal System

Supports Oestrogen Metabolism

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps support the healthy processing of oestrogen in the body.

Glandular System

This mechanism represents support for the body's own oestrogen metabolism and clearance pathways. It is not a claim to treat hormonal conditions or alter hormone levels therapeutically.

Supports Pancreatic Function

Mechanism Evidence: Moderate — Source: NHS

Glucose Regulation

Helps support healthy pancreas function.

Glandular System

This mechanism represents support for normal pancreatic function in blood glucose regulation. It is not a claim to treat diabetes or any pancreatic disorder, or to replace insulin or other prescribed medication.

Supports Phase I Detoxification

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Detoxification

Helps the liver begin breaking down toxins and unwanted compounds.

Digestive SystemImmune System

Supports Physical Performance

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps support physical performance and stamina.

Structural System

Supports Phytoestrogen Metabolism

Mechanism Evidence: Moderate — Source: NHS

Glandular

Supports the gut-mediated processing of plant compounds with oestrogen-like activity.

Glandular System

This mechanism represents metabolism and bioavailability of dietary phytoestrogens. It is not a claim that phytoestrogens replace endogenous oestrogen, treat menopause, or normalise hormone concentrations.

Supports Redox Balance

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Oxidative Stress

Helps keep the body's oxidative balance in a healthy range.

Immune SystemRespiratory System

Sources

Supports Renal Cellular Protection

Mechanism Evidence: Moderate — Source: NHS

Renal Function

Helps protect kidney cells from everyday stress and damage.

Urinary System

Supports Renal Microvascular Blood Flow

Mechanism Evidence: Moderate — Source: British Heart Foundation

Renal Function

Nitrate-rich foods and certain amino acids support healthy blood flow to the kidneys, in the same way they support blood flow elsewhere in the body.

Urinary SystemCirculatory System

This describes normal vascular physiology applied to renal blood flow and is not evidence for managing chronic kidney disease, hypertension-related kidney damage, or any diagnosed renal condition.

Supports Resolution of Inflammation

Mechanism Evidence: Moderate — Source: NHS

Immune Function

Helps the body properly wind down inflammation once it's no longer needed.

Immune System

Supports Sex Hormone Balance

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps support a healthy balance of sex hormones.

Glandular System

This mechanism represents support for normal physiological hormone balance. It is not a claim to treat hormonal disorders or replace hormone therapy.

Sources

Supports Skin Barrier & Photoprotection

Mechanism Evidence: Moderate — Source: NHS

Dermatological Function

Helps protect skin from everyday UV and environmental stress and supports its natural moisture barrier.

Skin, Hair & Nails

This reflects general antioxidant and skin-barrier support from diet. It is not a substitute for sunscreen or other sun-protection measures, and does not treat a diagnosed skin condition such as eczema, psoriasis or rosacea.

Sources

Supports Skin Carotenoid-Based Pigmentation

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Dermatological Function

Carotenoid-rich foods like tomatoes and carrots can subtly influence natural skin colour and glow.

Skin, Hair & Nails

Refers only to carotenoid-related skin colouration, not to sun protection, tanning, or treatment of pigmentation disorders such as vitiligo or melasma.

Supports Synaptic Plasticity

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Brain Function

Helps the brain form and strengthen new connections.

Brain & Nervous System

Sources

Supports Synovial Fluid Viscosity

Mechanism Evidence: Moderate — Source: NHS

Joint Health

Some nutrients help keep the fluid inside your joints slippery and cushioning.

Structural System

Refers to normal joint-lubrication physiology; not a claim to treat osteoarthritis or any joint disease.

Supports Tendon Health

Mechanism Evidence: Moderate — Source: NHS

Musculoskeletal Function

Helps keep tendons strong and resilient.

Structural System

Sources

Supports Testosterone Production

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Hormonal Function

Helps support the body's natural testosterone production.

Glandular System

This mechanism represents support for normal physiological testosterone production. It is not a claim to treat low testosterone or replace hormone therapy.

Sources

Supports Urinary Tract Epithelial Differentiation

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Renal Function

Provitamin A carotenoids support the normal renewal of the cells lining the urinary tract, similar to their role in other body linings.

Urinary System

This reflects vitamin A's well-established general role in epithelial tissue maintenance rather than urinary-tract-specific clinical evidence, and must not be read as addressing bladder pathology, dysplasia, or cancer risk.

Supports Urinary Tract Health

Mechanism Evidence: Moderate — Source: NHS

Renal Function

Helps stop certain bacteria from sticking to the walls of the urinary tract.

Urinary System

Supports Urinary Tract Lining's Resistance to Bacterial Adhesion

Mechanism Evidence: Moderate — Source: EFSA

Renal Function

Certain cranberry compounds and D-mannose make it physically harder for some bacteria to stick to the lining of the urinary tract.

Urinary System

Describes a physical anti-adhesion mechanism only; this is not evidence of preventing, treating, or reducing the risk of urinary tract infections, and no infection-prevention or treatment claim should be made from it.

Supports Vascular Resilience

Mechanism Evidence: Moderate — Source: British Heart Foundation

Vascular Function

Helps blood vessels stay resilient under everyday stress.

Circulatory System

Supports Xenobiotic Elimination

Mechanism Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Detoxification

Helps the body remove processed toxins and waste products.

Digestive SystemImmune System

Theaflavins

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavonoids

Distinctive black tea polyphenols formed during fermentation that support cardiovascular and antioxidant health.

Circulatory SystemImmune SystemRespiratory System

Thearubigins

Bioactive Evidence: Moderate — Source: British Dietetic Association

Polyphenols — Tea Polyphenols

The dark-coloured, complex polyphenols that make up most of black tea's polyphenol content, distinct from the smaller theaflavins.

Immune SystemRespiratory SystemCirculatory System

Sources

Theobromine

Bioactive Evidence: Moderate — Source: EFSA

Functional Compounds — Methylxanthines

A natural stimulant compound related to caffeine, found in kola nut and cacao, with a milder and longer-lasting effect.

Brain & Nervous SystemGlandular SystemStructural System

Thymol

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Terpenes — Monoterpenes

A thyme-derived terpene that supports normal immune function and antioxidant defence.

Brain & Nervous SystemGlandular SystemDigestive SystemIntestinal System

Thymoquinone

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Quinones

The signature active compound in nigella (black seed), long used in traditional medicine and studied for antioxidant and anti-inflammatory effects.

Immune System

Valerenic Acid

Bioactive Evidence: Moderate — Source: NHS

Functional Compounds — Calming Compounds

The characteristic active compound of valerian root, traditionally used to support calm and restful sleep.

Brain & Nervous System

Vitexin

Bioactive Evidence: Moderate — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Flavones

A natural plant flavone found notably in mung beans that contributes to their antioxidant activity.

Immune SystemRespiratory SystemGlandular System

Xanthones

Bioactive Evidence: Moderate — Source: EFSA

Polyphenols — Xanthones

A distinctive family of antioxidant plant pigments that give mangosteen its reputation as an antioxidant-rich fruit, though most of it sits in the rind rather than the part usually eaten.

Immune SystemRespiratory System

10-Hydroxy-2-Decenoic Acid (10-HDA)

Bioactive Evidence: Low — Source: EFSA

Fatty Acids — Hydroxy Fatty Acids

A unique fatty acid found almost exclusively in royal jelly, used to authenticate genuine royal jelly and studied for supporting normal immune cell activity.

Immune System

Apigenin

Bioactive Evidence: Low — Source: EFSA

Polyphenols — Flavones

A plant flavonoid found in celery seed, parsley and chamomile that contributes to celery's traditional reputation for supporting healthy circulation.

Circulatory SystemImmune SystemRespiratory System

Charantin

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Steroidal Glycosides

A group of plant compounds unique to bitter melon that have traditionally been used to support healthy blood sugar, though modern human trial results are inconsistent.

Glandular System

Chrysin

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Calming Compounds

A flavone found in passionflower, traditionally associated with a calming, sleep-supportive effect.

Brain & Nervous System

Ecdysterone

Bioactive Evidence: Low — Source: USDA FoodData Central

Functional Compounds — Phytoecdysteroids

A plant steroid found in spinach and quinoa that has attracted sports-nutrition interest for possible muscle-building effects, though the evidence is still early and mixed.

Structural System

Eleutherosides

Bioactive Evidence: Low — Source: EFSA

Functional Compounds — Adaptogenic Compounds

A group of plant compounds found in eleuthero (Siberian ginseng) root, traditionally associated with its 'adaptogen' reputation.

Structural SystemImmune System

Sources

Erinacines

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Mushroom Terpenoids

A family of terpenoid compounds unique to Lion's Mane mushroom, studied for their potential to support nerve growth factor activity and cognitive function.

Brain & Nervous System

Falcarinol

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Polyacetylenes

A natural plant compound found in carrots, parsnips, celery and fennel that is being studied for its role in supporting gut and cellular health.

Immune SystemRespiratory System

Ganoderic Acids

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Terpenes — Triterpenes

A group of naturally bitter compounds found in reishi mushroom that give it its traditional reputation, currently the subject of early-stage research.

Immune SystemRespiratory System

Green Algal Sulfated Polysaccharides

Bioactive Evidence: Low — Source: EFSA

Dietary Fibre — Sulfated Polysaccharides

A family of gel-forming fibres unique to green seaweeds, including the ulvan in sea lettuce, being studied as a source of fermentable dietary fibre.

Digestive SystemIntestinal SystemImmune System

Hydroxy-alpha-Sanshool

Bioactive Evidence: Low — Source: EFSA

Functional Compounds — Alkylamides

The compound responsible for Sichuan pepper's distinctive tingling, numbing sensation.

Brain & Nervous System

L-DOPA

Bioactive Evidence: Low — Source: EFSA

Functional Compounds — Amino Acid Derivatives

A naturally occurring compound found in unusually high amounts in velvet bean seeds that the body converts into dopamine.

Brain & Nervous System

Macamides

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Adaptogenic Compounds

Characteristic fatty acid amides found in maca root, associated with maca's traditional energy and vitality benefits.

Structural SystemGlandular System

Sources

Nobiletin

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Polyphenols — Polymethoxyflavones

A flavonoid concentrated in citrus peel rather than the flesh, studied for metabolic and anti-inflammatory effects.

Immune SystemCirculatory System

PQQ

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Quinones

A trace redox-active compound found in fermented soybeans and some plant foods, of growing interest for cellular energy production.

Immune SystemRespiratory System

Red Algal Sulfated Galactans

Bioactive Evidence: Low — Source: EFSA

Dietary Fibre — Sulfated Polysaccharides

A family of gel-forming fibres found only in red seaweeds, including the carrageenan in Irish moss and the porphyran in laver.

Digestive SystemIntestinal System

Scopoletin

Bioactive Evidence: Low — Source: EFSA

Polyphenols — Coumarins

A plant coumarin compound and one of the most studied constituents of noni fruit.

Immune SystemRespiratory System

Spermidine

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Polyamines

A naturally occurring compound, concentrated in aged and fermented foods, that is being studied for its role in supporting the body's own cellular 'clean-up' process as we age.

Immune SystemRespiratory System

Supports Bladder Urothelial Surface Layer Components

Mechanism Evidence: Low — Source: EFSA

Renal Function

Some of the same building blocks used for cartilage may also contribute to the protective surface layer of the bladder lining.

Urinary System

Evidence for oral intake reaching or restoring the bladder surface GAG layer is preliminary and indirect (most supporting data relates to direct bladder instillation, not diet); this must not be read as support for treating interstitial cystitis, bladder pain syndrome, or any bladder condition.

Supports Dermal Collagen Protection from Glycation

Mechanism Evidence: Low — Source: EFSA

Dermatological Function

Some plant polyphenols and the compound carnosine may help protect skin's existing collagen from sugar-related damage over time.

Skin, Hair & NailsStructural System

This describes a protective biochemical pathway under active research, not an anti-ageing, wrinkle-reduction, or skin-rejuvenation claim, and must not be framed as reversing skin ageing.

Supports Scalp Microcirculation

Mechanism Evidence: Low — Source: British Heart Foundation

Dermatological Function

Nitrate-rich vegetables support healthy blood flow to the scalp, in the same way they support blood flow elsewhere in the body.

Skin, Hair & Nails

This is extrapolated from general vascular physiology rather than scalp- or hair-specific clinical trials, and must not be read as a hair-loss treatment or regrowth claim.

Terpinen-4-ol

Bioactive Evidence: Low — Source: EFSA

Terpenes — Monoterpenes

A volatile oil compound found in juniper berry, traditionally associated with urinary tract flushing support.

Urinary SystemImmune System

Vanillin

Bioactive Evidence: Low — Source: EFSA

Functional Compounds — Aromatic Aldehydes

The main flavour compound in vanilla, which also has antioxidant activity in laboratory studies.

Immune SystemRespiratory System

Sources

Verbascoside

Bioactive Evidence: Low — Source: EFSA

Polyphenols — Phenylethanoid Glycosides

A distinctive antioxidant polyphenol that gives lemon verbena tea much of its characteristic phytochemical profile.

Immune SystemRespiratory System

Withanolides

Bioactive Evidence: Low — Source: EFSA

Functional Compounds — Adaptogenic Compounds

Naturally occurring plant steroid-like compounds found in ashwagandha root, central to its traditional 'adaptogen' reputation.

Structural SystemBrain & Nervous System

Xanthohumol

Bioactive Evidence: Low — Source: Harvard T.H. Chan School of Public Health

Functional Compounds — Calming Compounds

A characteristic flavonoid from hop flowers, traditionally associated with hops' calming, sleep-supportive properties.

Brain & Nervous SystemImmune SystemRespiratory System